A papillary hidradenoma, also hidradenoma papilliferum, is a sharply circumscribed nodule or benign tumor of the apocrine gland usually found on the labia majora or the interlabial folds. Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. Hidradenoma papilliferum of the vulva punch biopsy from. The differential diagnosis between this neoplasm and bartholin cysts and abscesses, lipoma and some premalignant and. Clear cell hidradenoma cch is a benign skin appendageal tumor. This is not bad and is harmless because complete surgical excision is curative. Hidradenoma papilliferum definition of hidradenoma. Histologically, it is a wellcircumscribed, nonencapsulated tumor formed of 2 cell types, one with clear cytoplasm and the other with dark eosinophilic cytoplasm. Terminology for vulvar cytology based on the bethesda system. It usually presents as an asymptomatic fleshcolored nodule in the anogenital area of. The literature cites 5 cases of ductal carcinoma in situ arising in association with hidradenoma papilliferum. This tumour is derived from anogenital mammary like glands 47. Hidradenoma papilliferum is a wellcircumscribed dermal nodule, usually without connection to the overlying. Malignant nodular hidradenoma is a rare skin appendageal tumor, and its imaging findings have not been previously described.
Vulvar hidradenoma papilliferum hp is located on the sites. It usually presents as an asymptomatic fleshcolored nodule in the anogenital area of women. A papillary hidradenoma, also hidradenoma papilliferum, is a sharply circumscribed nodule or. Hidradenoma papilliferum is a slowgrowing benign skinadnexal tumor with apocrine differentiation. Hidradenoma of the vulva jama dermatology jama network. It usually presents as slowly enlarging, solitary, freely movable, solid or cystic swelling, frequently diagnosed from fourth to eighth decade of life. Woringer, f sweat gland adenoma in a small tumor of the labia majora, bull. Acrospiroma nodular hidradenoma of the thigh mahe digital.
Hidroacanthoma can also be of apocrine or eccrine origin. Hoang harvard medical school massachusetts general hospital department of pathology boston, ma, usa maria angelica selim, md duke university medical center department of. Hidradenoma definition of hidradenoma by the free dictionary. Poroid hidradenoma is a rare benign neoplasm described by abenoza and ackerman in 1990 1. Hidradenoma papilliferum hp is a rare, small, benign, cystic, papillary, slow growing tumor occurring in anogenital region of adult women. They occur frequently on the scalp, face, abdomen, and extremities. Nodular hidradenoma, also known as clear cell hidradenoma or acrospiroma is a benign rare skin tumour arising from the eccrine type of sweat glands. This was a small cyst on my vulvar i had it for about 1 year before my gyno decided it was not going away on its own and should be removed. Benign, small, sharply circumscribed nodule covered by normal skin, often on labia majora or interlabial folds. Hidradenoma papilliferum of vulva is observed on the vulva external opening of vagina, commonly in middleaged women. Vulvar fibroadenomas are sporadic lesions informed in the literature and a controversy about origin has been discussed widely. All structured data from the file and property namespaces is available under the creative commons cc0 license. Aims hidradenoma papilliferum hp is a benign vulvar neoplasm that arises from anogenital mammarylike glands, and its morphology is similar to mammary intraductal papilloma. Dec 09, 2017 a hidradenoma is a growth that arises from the sweat gland distal excretory duct.
Although rare, inclusion of cch should be included in the differential diagnosis of benign. This distribution directly reflects the distribution of anogenital mammary like glands. Vulvar hidradenoma papilliferum hp is located on the. There are several types of hidradenomas that may develop anywhere on the. Hidradenoma papilliferum of the vulva punch biopsy from a. In vulva the sites of involvement include labia minora 50%, labia majora 40%, fourchette 7% and clitoris 3%. Intraductal carcinoma of mammarytype apocrine epithelium arising within a papillary hydradenoma of the vulva. The tumor usually presents as a solitary firm dermal nodule. Hidradenoma papilliferum of the vulva pubmed central pmc. It is a benign neoplasm with eccrine differentiation, originally described by abenoza and ackerman in 1990.
Nodular hidradenoma of the skin was first described by liu in 1949. Dec 11, 2018 nodular hidradenoma of vulva is a benign tumor. We experienced the case of a large malignant nodular hidradenoma of the left upper arm in a 71yearold woman. The endocrine glands, or ductless glands, discharge their secretions hormones directly into the blood. Hoang harvard medical school massachusetts general hospital department of pathology boston, ma, usa maria angelica selim, md duke university medical center department of pathology durham, nc, usa isbn 97814939. Tubules and broad, elongated fronds form an arborizing pattern and are lined with a doublelayered epithelium figures 2, 3.
Hidradenoma is a relatively rare tumor of sweat gland origin. We describe a case of an 26yearold man that presented. Apr 28, 2020 a hidradenoma is a benign cutaneous condition that primarily affects the skin on the cheek. A rare case presentation find, read and cite all the research you.
May derive from ectopic mammary tissue resembles intraductal papilloma. We focused specifically on pik3ca and akt1 mutations, which are both. The lesions usually present as an asymptomatic slowgrowing, red, firm, mobile, welldelimitated nodule that grows for a long time before resection. In our series, hidradenoma papilliferum was the mostcommon benign vulvar adnexal neoplasm, accounting for 60% of the benign lesions and 42% of the total vulvar adnexal neoplasms table 1. We report a case of a 19 years old woman with a large slow growing mass in the right labia majora with the final diagnosis of fibroadenoma with mammary tissue surrounding it and positive hormone receptors. Hidradenoma article about hidradenoma by the free dictionary. The lesions are skin colored or red and located on the vulva or perianal area 1. Eccrine naevi produce either a mucinous discharge or a localized area of excessive sweating hyperhidrosis, which can occur spontaneously or.
The lesion referred to is termed a hidradenoma, adenoma hidradenoides or hidradenoma tubulare. The aim of this study was to investigate oncogenic mutations involved in the tumourigenesis of hp. It has a nodular appearance and that is why this name is it. Feb 12, 2014 acrospiroma or nodular hidradenoma is a rare benign neoplasm arising from the eccrine sweat glands. Since then, less than 20 cases of poroid hidradenoma have been reported in the literature. Glaciset 43 a, 2800, lyngby, denmarksearch for more papers by this author. Additional and relevant useful information for nodular hidradenoma of vulva. A hidradenoma is a benign cutaneous condition that primarily affects the skin on the cheek. Werth 2 is generally credited with the first description of hidradenoma of the vulva. Hidradenoma definition of hidradenoma by medical dictionary. One paper reported a case of vulvar poroid hidradenoma, leading the authors to agree with others in that there is no true site of predilection.
Hidradenoma or acrospiroma is a benign dermal growth closely related to poroma except without connection to the epidermis. A hidradenoma is a growth that arises from the sweat gland distal excretory duct. Clear cell hidradenoma, also known as eccrine acrospiroma, usually presents as a solid and cystic nodule with no site predilection, although it is only rarely reported to occur on the vulva. Hoang maria angelica selim editors 123 vulvar pathology mai p. It is an important condition because, although benign, it is often mistaken in both its clinical and histopathologic aspects for an adenocarcinoma. Files are available under licenses specified on their description page. The tumor originates in the epithelium, cells that line the surface layer of connective tissue and of the sweat glands. Section showed the lumen was lined by columnar cells with oval staining nucleus located near base and faintly eosinophilic cytoplasm. N2 adenocarcinoma in situ rarely occurs in vulvar papillary hidradenoma. Herein we report a case of acrospiroma in a 50 year old male patient who presented with an asymptomatic, solitary. The glands within a sweat gland naevus are increased in size and number from birth. Wc vulva hidradenomapapilliferum ulcerated pa skb vulva hidradenomapapilliferum mp paskb vulva hidradenomapapilliferum lp paskb. This lesion is a small, infrequent, usually asymptomatic, almost always benign tumor arising from the large apocrine sweat glands of the vulva. Adenocarcinoma in situ arising in vulvar papillary.
There is no evidence to prove that oily foods and chocolatebased products have an influence on nodular hidradenoma of vulva formation. Hidradenoma presenting in a breast is exceedingly rare and this can potentially lead to. Hidradenoma papilliferum of the vulva abstract introduction. Hidradenoma papilliferum of the vulva a case report smita pathak, shruti desale, sneha joshi department of pathology, maharashtra institute of medical education and research, pune, maharashtra, india abstract c. Hidradenoma papilliferum is a rare tumor that occurs almost exclusively in females on the anogenital area. Hidradenoma papilliferum of the vulva a case report smita pathak, shruti desale, sneha joshi. Learn indepth information on hidradenoma papilliferum of vulva, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. The literature cites 5 cases of ductal carcinoma in situ arising in. Eccrine and apocrine naevi are rare malformations of the glandular component of an eccrine or apocrine gland.
Also known as papillary hidradenoma benign, small, sharply circumscribed nodule covered by normal skin, often on labia majora or interlabial folds may ulcerate through skin and simulate carcinoma may derive from ectopic mammary tissue resembles intraductal papilloma. Hidradenoma papilliferum of the vulva a case report. Poroid hidradenoma is a rare cutaneous neoplasm, most frequently situated on head and neck. Hidradenoma papilliferum american journal of clinical. We report a case of cch in a very unusual location. Hidradenomas are often subclassified based on subtle histologic differences, for example. Rare cases of ectopic nongenital hidradenoma papilliferum have been described. Nodular hidradenoma of anterior abdominal wall rudraraju. Hidradenoma papilliferum is a rare benign tumor of apocrine glands. They classified poromas into four groups according to structural features. Hidradenoma papilliferum of the vulva presenting as a. View the article pdf and any associated supplements and figures for a period of 48 hours. It occurs commonly on the vulval or perianal regions of.
It appears as a solitary nodule lump or cyst when it is called cystic hidradenoma and may appear on any site. Nodular hidradenoma may also be referred to as clear cell hidradenoma when there is a prominent clear cell component or eccrine acrospiroma. Vulvar pathology vulvar pathology mai p hoang maria. Pik3ca and akt1 mutations in hidradenoma papilliferum. Hidradenoma papilliferum was first reported by worth in 1878 and the most common sites are vulva and perianal regions. We focused specifically on pik3ca and akt1 mutations, which are both reported to be detected in 33% of mammary. A nodular hidradenoma is a benign adnexal tumor of eccrine sweat gland origin. Histopathologically, hidradenoma is characterized by multilobulated, circumscribed, yet unencapsulated, tumor. Poroid hidradenoma is a recently recognized variant of poroid neoplasm that should be differentiated from apocrine hidradenoma 1. Differential diagnostic problems are discussed, emphasizing in particular the possibility of confusing this tumour with ep. Although traditionally regarded as displaying eccrine differentiation, it is now accepted that tumors can show either eccrine or apocrine differentiation. The etiology of hidradenoma papilliferum is unknown. I have just been diagnosed with hidradenoma papilliferum.
Hidroadenoma papilliferum hp is a rare benign tumor of the vulva that grows mainly in the skin of the anogenital region of adult women. It is a slowgrowing and usually solitary tumor that occurs as a painless papule. Hidradenoma papilliferum is a wellcircumscribed dermal nodule, usually without connection to the overlying epidermis figure 1. These findings were compatible with poroid hidradenoma, which is a benign dermal tumor. Hidradenoma papilliferum, also called papillary hidradenoma, is benign tumour arising from apocrine glands see sweat gland lesions. T1 adenocarcinoma in situ arising in vulvar papillary hidradenoma.
Hidradenomas are commonly encountered on face, upper extremity, axilla, trunk, thigh, scalp and pubis 2. Mri revealed a large, lobular, poorly circumscribed, soft tissue mass at the left upper arm. Nodular hidradenoma is a variant of benign cutaneous adnexal tumors which arises from eccrine sweat glands. It is common in vulvar topography and rare in the perianal region. Nodular hidradenoma is a benign dermal tumor that arises from the distal excretory duct of eccrine sweat gland most of the tumors reported in the literature are small round red or skin colored nodules or sometimes subcutaneous lesions are misdiagnosed as epidermoid cysts. Hidradenoma papilliferum is a rare benign cystic and papillary neoplasm arising from apocrine glands.
The microscopic appearances of vulval hidroadenoma are described. To the best of our knowledge, cch has not been previously described in this site, in the english literature. Pdf on nov 10, 2017, kafil akhtar and others published papillary hidradenoma of vulva. The clinical appearance of this lesion is not specific and differential diagnosis can only be done after complete removal of the lesion. Hidradenoma papilliferum is a benign cystic tumor originated in apocrine sweat glands of the anogenital region. All hidradenoma papilliferum messages cancercompass. Less frequent sites include the axilla, trunk and extremities. Nos descrevemos o, histopatologicos e revisou a literatura disponivel clinica relacionada a doenca. Hidradenoma papilliferum hp, also known as papillary hidradenoma, is a benign, slowgrowing, asymptomatic, adnexal tumor that primarily affects the anogenital area of adult women and, much more rarely, ectopic sites, such as the ears, face, scalp, chest, and abdomen.
Glands are divided into two main groups, endocrine and exocrine. It presents architectural features of hidradenoma, with solid and cystic areas and tumor cells restricted to the dermis, and cytological features of poroid neoplasm such as poroid and cuticular cells. Hidradenoma papilliferum is a benign tumor of the apocrine glands that occurs in the female anogenital region, most often in women between 2540 years of age. Sep 28, 2018 learn indepth information on hidradenoma papilliferum of vulva, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis.
The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva histology of hidradenoma papilliferum. Please remove adblock adverts are the main source of revenue for dovemed. The differential diagnosis between this neoplasm and bartholin cysts and abscesses, lipoma and some premalignant and malignant vulvar lesions can be difficult. A fragmented overlying epidermis is seen at the top of the image. It presents architectural features of hidradenoma, with solid and cystic areas and tumor cells restricted to the dermis, and cytological features of poroid. Papillary hidradenoma, also hidradenoma papilliferum, is a benign lesion typically found in the vulva. It usually presents as a single, small skincolored lesion, and is considered distinct from the closely related poroma. Hoang maria angelica selim editors vulvar pathology editors mai p. Acrospiroma or nodular hidradenoma is a rare benign neoplasm arising from the eccrine sweat glands. Although most cases are benign, occasional cases with malignant transformation have been reported. Nodular hidradenoma of anterior abdominal wall rudraraju sr. It is benign tissue not cancerous but is often confused clinically with carcinoma of the vulva because of its tendency to ulcerate. It first appears as a small dark colored fluidfilled growth.
748 1346 849 1476 810 294 1275 484 1537 7 1173 592 309 172 1180 1035 1155 511 854 491 664 127 412 1426 11 120 1411 1400 453 846 1112 1074 448 1261 455 174 127 125 161 930 368 1328 1232 270 19 989